Negotiations between the United States and Iran in Islamabad have ended without agreement after 21 hours of talks hosted by Pakistan.

Iranian Foreign Ministry spokesman Esmaeil Baghaei said discussions covered nuclear issues, sanctions relief, the Strait of Hormuz, and regional tensions, noting that both sides exchanged proposals.

US Vice President J. D. Vance confirmed no consensus was reached and said the US delegation would return home, thanking Pakistan for its mediation role.

He said the main sticking point remains Iran’s nuclear ambitions, with Washington demanding a firm commitment not to develop nuclear weapons, a position he described as a “red line” set by President Donald Trump.

The failure to reach a deal leaves a fragile ceasefire under strain and raises concerns over renewed tensions in the region.